Mert Tufan
University of Cukurova, Faculty of Medicine, Department of Biophysics, 01330 Balcali, Adana, Turkey.
Eur J Pharmacol. 2007 Jul 30;568(1-3):25-30. doi: 10.1016/j.ejphar.2007.05.004. Epub 2007 May 13.
Ion channels are fundamental to the correct functioning of nerves. A high density of Na(v) channels at nodes of Ranvier is crucial for generating sufficient local current to initiate a self-regenerating action potential. K(v)7 (KCNQ) channels are also functional components of nodes of Ranvier and contribute to the repolarization of the action potential. Paranodes underlying the paranodal loops have no channels whereas K(v)1.1 and K(v)1.2 channels cluster at juxtaparanodes. The disruption of the normal balance of different channels causes the inappropriate nerve activity that underlies a variety of nervous system diseases. Axonal voltage-dependent channels, nodal Na(v) and juxtaparanodal K(v) channels disperse after the nerve injury and reorganize with regeneration.
离子通道对于神经的正常功能至关重要。郎飞结处高密度的Na(v)通道对于产生足够的局部电流以启动自我再生动作电位至关重要。K(v)7（KCNQ）通道也是郎飞结的功能组成部分，并有助于动作电位的复极化。节旁环下方的结旁区没有通道，而K(v)1.1和K(v)1.2通道聚集在近结旁区。不同通道正常平衡的破坏会导致不适当的神经活动，这是多种神经系统疾病的基础。轴突电压依赖性通道、结处的Na(v)通道和近结旁处的K(v)通道在神经损伤后会分散，并随着再生而重新组织。
