Agledahl Ingvild, Skjaerpe Paal-André, Hansen John-Bjarne, Svartberg Johan
Department of Medicine, University Hospital of North Norway, 9038 Tromsø, Norway.
Nutr Metab Cardiovasc Dis. 2008 May;18(4):256-62. doi: 10.1016/j.numecd.2007.01.014. Epub 2007 Jun 8.
To study the relationships between endogenous testosterone, sex hormone-binding globulin (SHBG) and serum lipids in non-fasting men.
We performed a cross-sectional study in 1274 men without known cardiovascular disease who participated in a population-based study, the 1994/1995 Tromsø study. Anthropometric characteristics were measured and questionnaires regarding lifestyle and medical history were completed. Non-fasting blood samples were drawn between 08.00 and 16.00h, and total testosterone, SHBG, triglycerides (TG), total cholesterol (TC) and high-density lipoprotein (HDL) were analyzed.
In stratified analyses based on sampling time, a linear increase in serum TG levels was found in men with total testosterone levels below the 50th percentile during the day (p for trend=0.004). In contrast, serum triglycerides did not change during the day in men with testosterone levels above the 50th percentile. In regression analyses, total testosterone and SHBG were inversely and independently associated with TG (p<0.001 and p<0.001 respectively), and positively and independently associated with HDL (p=0.005 and p<0.001, respectively). Men with an unfavorable lipid profile (HDL <0.90 and TG >1.8) had significantly lower levels of total testosterone and SHBG (p=0.004 and p<0.001, respectively) in age and BMI adjusted analyses, compared to men with a normal lipid profile.
Low serum total testosterone was associated with a linear increase in serum TG during the day, and was independently associated with an unfavorable lipid profile. Our findings may indicate that low total testosterone is associated with impaired TG metabolism in men.
研究非空腹男性体内内源性睾酮、性激素结合球蛋白（SHBG）与血脂之间的关系。
我们对1274名无已知心血管疾病的男性进行了一项横断面研究，这些男性参与了一项基于人群的研究，即1994/1995年特罗姆瑟研究。测量了人体测量学特征，并完成了关于生活方式和病史的问卷调查。在08:00至16:00之间采集非空腹血样，分析总睾酮、SHBG、甘油三酯（TG）、总胆固醇（TC）和高密度脂蛋白（HDL）。
在基于采样时间的分层分析中，白天总睾酮水平低于第50百分位数的男性血清TG水平呈线性升高（趋势p=0.004）。相比之下，睾酮水平高于第50百分位数的男性血清甘油三酯在白天没有变化。在回归分析中，总睾酮和SHBG与TG呈负相关且独立相关（分别为p<0.001和p<0.001），与HDL呈正相关且独立相关（分别为p=0.005和p<0.001）。与血脂正常的男性相比，在年龄和BMI校正分析中，血脂谱不佳（HDL<0.90且TG>1.8）的男性总睾酮和SHBG水平显著较低（分别为p=0.004和p<0.001）。
低血清总睾酮与白天血清TG的线性升高相关，且与不良血脂谱独立相关。我们的研究结果可能表明，低总睾酮与男性TG代谢受损有关。
