Dengri Chetna, Koriesh Ahmed, Babi Marc A, Mayberry Whitney, Goldstein Eric D, Pervez Mubashir, Nouh Amre
Department of Neurology, Cleveland Clinic Florida, Weston, FL, United States.
Department of Neurology, Cleveland Clinic Florida, Port St. Lucie, FL, United States.
Front Neurol. 2024 Sep 2;15:1422931. doi: 10.3389/fneur.2024.1422931. eCollection 2024.
Testosterone supplementation has increased in recent years for both treatment of hypogonadism and recreational use. Strokes in young adults have similarly increased with a larger proportion of patients in this age group having a stroke due to early onset of cardiovascular risk factors or unrelated to conventional risks. Hormonal treatments are associated with increased stroke risk amongst women, with some studies indicating an increase in stroke risk as high as 40% when compared to non-users. However, less is known about male sex hormones and risks associated with increased stroke. Limited data evaluates the relationship between testosterone supplementation and stroke in young adults. In this review, we analyze the literature and plausible underlying pathophysiological mechanisms associated with increased risks in patients using exogenous testosterone. Furthermore, we highlight the gaps in research about safety and long-term effects on young patients.
近年来，睾酮补充疗法在性腺功能减退治疗及娱乐用途方面的应用均有所增加。年轻人中风的发生率也同样上升，该年龄组中因心血管危险因素早期发作或与传统风险无关而中风的患者比例更高。激素治疗会增加女性中风风险，一些研究表明，与未使用者相比，中风风险增幅高达40%。然而，关于男性性激素及与中风风险增加相关的研究较少。有限的数据评估了年轻人补充睾酮与中风之间的关系。在本综述中，我们分析了相关文献以及使用外源性睾酮的患者风险增加背后可能的病理生理机制。此外，我们强调了在年轻患者安全性和长期影响方面的研究空白。
