Prepin J
Collège de France, Laboratoire de Physiologie du Développement, Paris.
C R Acad Sci III. 1991;313(9):407-11.
In rat ovaries explanted on day 13.5 p.c. and cultured in vitro for up to 6 days, the number of germ cells is enhanced in thymulin-supplemented medium and/or after co-culture of the ovarian explants with foetal thymic tissue compared to ovaries cultured in synthetic medium. Corticosterone added to the medium prevents the secretion of thymulin by the foetal thymus and in that condition the thymus does not influence the proliferation of oogonia. These results provide additional evidence that the pituitary-adrenal-thymic axis might be involved in the control of oogonia proliferation in vivo, taking into account our previous experimental finding that the number of germ cells is increased in ovaries of hypophysectomized foetuses.
在妊娠13.5天取出的大鼠卵巢并在体外培养长达6天，与在合成培养基中培养的卵巢相比，在补充了胸腺素的培养基中培养和/或卵巢外植体与胎儿胸腺组织共培养后，生殖细胞数量增加。添加到培养基中的皮质酮可阻止胎儿胸腺分泌胸腺素，在这种情况下，胸腺不影响卵原细胞的增殖。考虑到我们之前的实验结果，即垂体切除胎儿的卵巢中生殖细胞数量增加，这些结果提供了额外的证据，表明垂体-肾上腺-胸腺轴可能参与体内卵原细胞增殖的控制。
