通过分析15个STR基因座对中国两个藏族群体的基因特征进行研究。

Genetic profile of two Tibetan populations from China by analysis of 15 STR loci.

作者信息

Ying Binwu, Liu Tingting, Chen Guo, Zhao Zhihe, Fan Hong, Wen Fuqiang

机构信息

Department of Respiratory Medicine and National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.

出版信息

Hum Biol. 2006 Dec;78(6):757-70. doi: 10.1353/hub.2007.0018.

DOI:10.1353/hub.2007.0018

PMID:17564254

Abstract

Allele frequency data for the STR systems D3S1358, TH01, D21S11, D18S51, PENTAE, D5S818, D13S317, D7S820, D16S539, CSF1PO, PENTAD, VWA, D8S1179, TPOX, and FGA were determined in two population samples of unrelated, healthy Tibetan individuals. All loci met Hardy-Weinberg expectations, and there was no evidence of association of alleles among the 15 loci. These findings suggest that these STR loci could be particularly powerful tools in forensic medicine and could provide the necessary fundamental population genetic data for the reconstruction of recent human evolutionary history.

摘要

在两个不相关的健康藏族个体群体样本中，测定了STR系统D3S1358、TH01、D21S11、D18S51、PENTAE、D5S818、D13S317、D7S820、D16S539、CSF1PO、PENTAD、VWA、D8S1179、TPOX和FGA的等位基因频率数据。所有位点均符合哈迪-温伯格预期，且15个位点之间没有等位基因关联的证据。这些发现表明，这些STR位点可能是法医学中特别强大的工具，并可为重建近代人类进化史提供必要的基础群体遗传数据。