Li Zhenghui, Zhang Jian, Zhang Hantao, Lin Ziqing, Ye Jian
Department of Forensic Medicine, Criminal Investigation Police University of China, No. 83, Tawan Street, Huanggu District, Shenyang, Liaoning, 110854, China.
Institute of Forensic Science, Ministry of Public Security, Beijing, 100038, China.
Int J Legal Med. 2018 May;132(3):733-734. doi: 10.1007/s00414-017-1740-1. Epub 2017 Nov 18.
Short tandem repeats (STRs) play a vitally important role in forensics. Population data is needed to improve the field. There is currently no large population data-based data set in Chamdo Tibetan. In our study, the allele frequencies and forensic statistical parameters of 18 autosomal STR loci (D5S818, D21S11, D7S820, CSF1PO, D2S1338, D3S1358, VWA, D8S1179, D16S539, PentaE, TPOX, TH01, D19S433, D18S51, FGA, D6S1043, D13S317, and D12S391) included in the DNATyper™19 kit were investigated in 2249 healthy, unrelated Tibetan subjects living in Tibet Chamdo, Southwest China. The combined power of discrimination and the combined probability of exclusion of all 18 loci were 0.9999999999999999999998174 and 0.99999994704, respectively. Furthermore, the genetic relationship between our Tibetan group and 33 previously published populations was also investigated. Phylogenetic analyses revealed that the Chamdo Tibetan population is more closely related genetically with the Lhasa Tibetan group. Our results suggest that these autosomal STR loci are highly polymorphic in the Tibetan population living in Tibet Chamdo and can be used as a powerful tool in forensics, linguistics, and population genetic analyses.
短串联重复序列（STRs）在法医学中起着至关重要的作用。该领域的发展需要群体数据。目前尚无基于昌都藏族大群体数据的数据集。在我们的研究中，对居住在中国西南部西藏昌都地区的2249名健康、无亲缘关系的藏族受试者，调查了DNATyper™19试剂盒中包含的18个常染色体STR基因座（D5S818、D21S11、D7S820、CSF1PO、D2S1338、D3S1358、VWA、D8S1179、D16S539、PentaE、TPOX、TH01、D19S433、D18S51、FGA、D6S1043、D13S317和D12S391）的等位基因频率和法医学统计参数。所有18个基因座的联合鉴别力和联合排除概率分别为0.9999999999999999999998174和0.99999994704。此外，还研究了我们藏族群体与33个先前发表的群体之间的遗传关系。系统发育分析表明，昌都藏族群体与拉萨藏族群体在遗传上关系更为密切。我们的结果表明，这些常染色体STR基因座在居住在西藏昌都的藏族群体中具有高度多态性，可作为法医学、语言学和群体遗传分析的有力工具。
