6例滤泡性甲状腺腺瘤的细胞遗传学，包括1例伴t(8;14)(q13;q24.1)的嗜酸性变的病例报告

Cytogenetics of six follicular thyroid adenomas including a case report of an oxyphil variant with t(8;14)(q13;q24.1).

作者信息

Herrmann M A, Hay I D, Bartelt D H, Spurbeck J L, Dahl R J, Grant C S, Jenkins R B

机构信息

Cytogenetics Laboratory, Mayo Clinic, Rochester, MN 55905.

出版信息

Cancer Genet Cytogenet. 1991 Oct 15;56(2):231-5. doi: 10.1016/0165-4608(91)90175-t.

DOI:10.1016/0165-4608(91)90175-t

PMID:1756468

Abstract

Cytogenetic analyses were performed on six follicular thyroid adenomas. Five had normal karyotypes and one, an oxyphil adenoma, had a t(8;14)(q13;q24.1). This patient also had a history of pleomorphic adenoma of the parotid gland. This clonal abnormality may suggest a primary genetic lesion in this patient who had two different benign neoplasms.

摘要

对六个滤泡性甲状腺腺瘤进行了细胞遗传学分析。五个核型正常，一个嗜酸细胞腺瘤有t(8;14)(q13;q24.1)。该患者既往有腮腺多形性腺瘤病史。这种克隆性异常可能提示该患有两种不同良性肿瘤的患者存在原发性基因病变。