Denis J, Rautou P E, Lambare B, Herbert S, Auray-Cartier V, Asselah T
Service d'Hépato-Gastroenterologie, Centre Hospitalier Sud-Francilien, quartier du Canal-Courcouronnes, 91014 Evry Cedex, France.
Infection. 2007 Jun;35(3):197-200. doi: 10.1007/s15010-007-6099-7.
When hepatitis C virus (HCV) infection becomes chronic, spontaneous viral eradication is a rare event. We report two patients with chronic hepatitis C, non-responders to standard interferon alone. They were treated with Pegylated interferon plus ribavirin. At the end of therapy, HCV RNA was still detectable. Several months after stopping treatment, aminotransferase level normalized and HCV RNA became undetectable. No case of sustained viral response happening several months after therapy has been yet described. During long-term follow-up of non-responders, when a persistent normalization of aminotransferase level is observed after stopping treatment, viral clearance could be suspected.
当丙型肝炎病毒（HCV）感染转为慢性时，病毒自发清除的情况极为罕见。我们报告了两名慢性丙型肝炎患者，他们对单独使用标准干扰素治疗无反应。他们接受了聚乙二醇化干扰素联合利巴韦林治疗。治疗结束时，HCV RNA仍可检测到。停止治疗数月后，转氨酶水平恢复正常，HCV RNA检测不到。尚未有关于治疗数月后出现持续病毒学应答的病例报道。在对无反应者的长期随访中，当停止治疗后观察到转氨酶水平持续正常时，可能怀疑病毒已清除。
