Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Gut Liver. 2011 Mar;5(1):110-4. doi: 10.5009/gnl.2011.5.1.110. Epub 2011 Mar 16.
Hepatitis C virus (HCV) infection usually progresses to chronic hepatitis, with rare cases of spontaneous viral eradication. We present herein four cases involving patients that were initially declared to have failed to respond to treatments, based on the presence of HCV RNA that was still detectable after completion of the standard treatment for chronic hepatitis C with genotype 2. However, the HCV RNA became undetectable, with a delayed response, after discontinuation of therapy. Two of the four patients were diagnosed as treatment failures after extended treatment, and the other two received no further treatment after the standard treatment. All four patients maintained a sustained virological response during the periodic follow-up after delayed viral clearance.
丙型肝炎病毒（HCV）感染通常会进展为慢性肝炎，极少数情况下会自发清除病毒。我们在此介绍 4 例患者，这些患者最初被诊断为对治疗无应答，原因是在完成慢性丙型肝炎基因型 2 的标准治疗后，仍可检测到 HCV RNA。然而，在停止治疗后，HCV RNA 出现延迟应答而转为不可检测。这 4 例患者中的 2 例在延长治疗后被诊断为治疗失败，另外 2 例在标准治疗后未再接受进一步治疗。所有 4 例患者在延迟病毒清除后的定期随访中均保持持续病毒学应答。
