Ohta M, Itoh M, Hara H, Itoh N, Nishitani H, Hayashi K, Ohta K
Clinical Research Center, Utano National Hospital, Kyoto, Japan.
Clin Chim Acta. 1991 Sep 30;201(3):201-5. doi: 10.1016/0009-8981(91)90371-i.
We measured the anti-skeletal muscle (SM) antibody titers in sera from 46 patients with thymoma but without Myasthenia gravis (MG) in order to determine whether the presence of anti-SM antibody is linked to the combination of thymoma-MG, or to thymoma alone. We detected anti-SM antibodies in 18 of these sera, of which 15 had concomitantly elevated titers of anti-AChR antibodies. Moreover, 9 of whom had experienced the onset of MG after surgery. In contrast, no patient without elevations in both antibodies developed MG during the followup. We conclude that the presence of anti-SM antibodies is linked strongly with thymoma associated with MG, but not with thymoma alone.
我们检测了46例胸腺瘤但无重症肌无力（MG）患者血清中的抗骨骼肌（SM）抗体滴度，以确定抗SM抗体的存在是否与胸腺瘤 - MG的组合有关，还是仅与胸腺瘤有关。我们在这些血清中的18例中检测到抗SM抗体，其中15例同时抗乙酰胆碱受体（AChR）抗体滴度升高。此外，其中9例在手术后出现了MG。相比之下，在随访期间，两种抗体均未升高的患者均未发生MG。我们得出结论，抗SM抗体的存在与MG相关的胸腺瘤密切相关，但与单独的胸腺瘤无关。
