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门诊胃肠外抗菌治疗(OPAT):对选定患者而言,在家自行给药是否安全?一项针对超过13年的大型队列的回顾性分析

Outpatient parenteral antimicrobial therapy (OPAT): is it safe for selected patients to self-administer at home? A retrospective analysis of a large cohort over 13 years.

作者信息

Matthews Philippa C, Conlon Christopher P, Berendt Anthony R, Kayley Jill, Jefferies Lorrayne, Atkins Bridget L, Byren Ivor

机构信息

Oxford Radcliffe Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK.

出版信息

J Antimicrob Chemother. 2007 Aug;60(2):356-62. doi: 10.1093/jac/dkm210. Epub 2007 Jun 11.

Abstract

OBJECTIVES

Provision of outpatient parenteral antimicrobial therapy (OPAT) is an evolving field, facilitating discharge from hospital for selected patients with serious infections. We report on a large OPAT cohort focusing on the practice of supervised parenteral antibiotic administration in the community by patients and relatives, which we collectively term 'self-administration'. To distinguish between healthcare professional OPAT and self-administered OPAT, we have coined the terms H-OPAT and S-OPAT, respectively.

PATIENTS AND METHODS

We analysed data on 2059 OPAT episodes collected prospectively over a 13 year time period from 1993 to 2005.

RESULTS

Clinical diagnosis, microbiology and antibiotics in this OPAT series are comparable to those previously reported. We identified no excess complications or hospital re-admissions in the S-OPAT group compared with the H-OPAT group.

CONCLUSIONS

Self-administration of intravenous antimicrobial therapy, in selected patients under the supervision of a specialist team, is a safe and feasible strategy.

摘要

目的

门诊胃肠外抗菌治疗(OPAT)是一个不断发展的领域,有助于特定严重感染患者出院。我们报告了一个大型OPAT队列,重点关注患者及其亲属在社区中进行的胃肠外抗生素监督给药实践,我们将其统称为“自我给药”。为区分医疗专业人员进行的OPAT和自我给药的OPAT,我们分别创造了术语H-OPAT和S-OPAT。

患者与方法

我们分析了1993年至2005年13年间前瞻性收集的2059例OPAT病例的数据。

结果

该OPAT系列中的临床诊断、微生物学和抗生素使用情况与先前报告的情况相当。我们发现,与H-OPAT组相比,S-OPAT组没有额外的并发症或再次入院情况。

结论

在专科团队的监督下,对特定患者进行静脉抗菌治疗的自我给药是一种安全可行的策略。

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