Wu Yong-Gui, Xia Ling-Ling, Lin Hui, Zhou Dian, Qian Hao, Lin Shan-Tan
Department of Nephrology, The First Affiliated Hospital, Anhui Medical University, Hefei, P. R. China.
Planta Med. 2007 May;73(5):433-8. doi: 10.1055/s-2007-967182.
The aim of this study was to investigate the protective effect of breviscapine extracted from the Chinese herb Erigeron breviscapus on liver injury in diabetic rats induced by streptozotocin. Treatment with breviscapine significantly reduced liver weight, liver lipid level, fatty liver and liver fibrosis score in diabetic rats. Treatment with breviscapine also significantly decreased lipid peroxidation malondiadehyde levels and increased the activities of antioxidative enzymes such as superoxide dismutase, catalase and glutathione peroxidase in diabetic liver. Immunohistochemical observations revealed that macrophage (ED-1-positive cells) infiltration in diabetic liver was inhibited by treatment with breviscapine. Western blot analysis showed that the expression of transforming growth factor-beta1 in diabetic liver was lowered by breviscapine treatment. In conclusion, our results indicate that breviscapine has potential as a treatment for diabetic liver injury through attenuating liver lipid accumulation and oxidative stress.
本研究旨在探讨从中药灯盏花中提取的灯盏花素对链脲佐菌素诱导的糖尿病大鼠肝损伤的保护作用。灯盏花素治疗显著降低了糖尿病大鼠的肝脏重量、肝脏脂质水平、脂肪肝和肝纤维化评分。灯盏花素治疗还显著降低了糖尿病肝脏中脂质过氧化丙二醛水平，并增加了抗氧化酶如超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性。免疫组织化学观察显示，灯盏花素治疗可抑制糖尿病肝脏中巨噬细胞（ED-1阳性细胞）浸润。蛋白质印迹分析表明，灯盏花素治疗可降低糖尿病肝脏中转化生长因子-β1的表达。总之，我们的结果表明，灯盏花素通过减轻肝脏脂质积累和氧化应激，具有治疗糖尿病肝损伤的潜力。
