Shuvalov Oleg, Kizenko Alyona, Petukhov Alexey, Fedorova Olga, Daks Alexandra, Barlev Nikolai
Institute of cytology RAS, St-Petersburg, Russia.
Almazov Federal North-West Medical Research Centre, St-Petersburg, Russia.
Cell Death Discov. 2021 May 8;7(1):97. doi: 10.1038/s41420-021-00482-4.
Cancer-testicular Antigens (CTAs) belong to a group of proteins that under normal conditions are strictly expressed in a male's reproductive tissues. However, upon malignisation, they are frequently re-expressed in neoplastic tissues of various origin. A number of studies have shown that different CTAs affect growth, migration and invasion of tumor cells and favor cancer development and metastasis. Two members of the CTA group, Semenogelin 1 and 2 (SEMG1 and SEMG2, or SEMGs) represent the major component of human seminal fluid. They regulate the motility and capacitation of sperm. They are often re-expressed in different malignancies including breast cancer. However, there is almost no information about the functional properties of SEMGs in cancer cells. In this review, we highlight the role of SEMGs in the reproductive system and also summarize the data on their expression and functions in malignant cells of various origins.
癌-睾丸抗原（CTA）属于一组在正常情况下仅在男性生殖组织中严格表达的蛋白质。然而，在发生恶性病变时，它们常常在各种来源的肿瘤组织中重新表达。大量研究表明，不同的CTA会影响肿瘤细胞的生长、迁移和侵袭，并促进癌症的发展和转移。CTA组的两个成员，精液凝胶蛋白1和2（SEMG1和SEMG2，或统称为SEMGs）是人类精液的主要成分。它们调节精子的活力和获能。它们经常在包括乳腺癌在内的不同恶性肿瘤中重新表达。然而，关于SEMGs在癌细胞中的功能特性几乎没有相关信息。在这篇综述中，我们重点介绍了SEMGs在生殖系统中的作用，并总结了它们在各种来源恶性细胞中的表达和功能的数据。
