Pola P, Flore R, Serricchio M, Tondi P
Department of Clinical Medicine, Catholic University of The Sacred Heart, Rome, Italy.
Drugs Exp Clin Res. 1991;17(5):277-82.
The treatment of arterial and venous cutaneous ulcers in vasculopathic patients is a difficult task, since it requires the prolonged administration of drugs which are often unable to correct the various pathogenetic factors, including rheological disorders, responsible for the lesions. The authors, basing themselves upon recent studies demonstrating the rheological and vasoactive as well as metabolic activities of propionyl l-carnitine, have decided to examine this substance for the treatment of arterial and venous cutaneous ulcers of the lower extremities. Propionyl l-carnitine administered orally or intravenously to eighteen vasculopathics with cutaneous ulcers was responsible for the complete or nearly complete regression of trophic lesions in 78.9% of the patients. Therapeutic failure or only modest results were observed in four patients. In addition a highly significant increase in flow velocity was observed in arteriopathic patients. It is particularly important to note that these clinical results were obtained in patients refractory to all other forms of therapy.
治疗血管病变患者的动静脉皮肤溃疡是一项艰巨的任务，因为这需要长期使用药物，而这些药物往往无法纠正导致病变的各种致病因素，包括流变学紊乱。基于最近的研究表明丙酰-L-肉碱具有流变学、血管活性以及代谢活性，作者决定研究该物质用于治疗下肢动静脉皮肤溃疡。对18名患有皮肤溃疡的血管病变患者口服或静脉注射丙酰-L-肉碱后，78.9%的患者出现了营养性病变完全或几乎完全消退。4名患者出现治疗失败或仅有轻微效果。此外，在动脉病变患者中观察到血流速度显著增加。特别需要注意的是，这些临床结果是在对所有其他治疗形式均无效的患者中获得的。
