Darke Shane, Ross Joanne, Williamson Anna, Mills Katherine L, Havard Alys, Teesson Maree
National Drug and Alcohol Research Centre, University of New South Wales, Australia.
Addiction. 2007 Jul;102(7):1140-6. doi: 10.1111/j.1360-0443.2007.01876.x.
To determine the effects of borderline personality disorder (BPD) on 36-month outcomes for the treatment of heroin dependence.
Longitudinal cohort study.
Sydney, Australia.
A total of 429 heroin users enrolled in the Australian Treatment Outcome Study, interviewed at 36-month follow-up.
The BPD group enrolled in significantly more different treatment episodes across follow-up, but there was no difference in the cumulative number of treatment days received. At 36 months, there were no group differences in sustained or current heroin abstinence, daily heroin use or level of polydrug use. BPD patients maintained significantly higher levels of crime, injection-related health problems, heroin overdose, major depression and poorer global mental health. In contrast to 12-month follow-up, at 36 months there were no group differences in the proportions who attempted suicide over the preceding 12 months or had recently borrowed used injection equipment.
The clinical picture provided some cause for optimism since 12-month follow-up. Despite this, BPD patients maintained elevated risk levels across a number of domains. The fact that these risks were maintained indicates that this is a group that requires specific clinical attention for BPD-related risks.
确定边缘性人格障碍(BPD)对海洛因依赖治疗36个月结果的影响。
纵向队列研究。
澳大利亚悉尼。
共有429名海洛因使用者参与了澳大利亚治疗结果研究,并在36个月随访时接受访谈。
在随访期间,BPD组参加的不同治疗疗程明显更多,但接受治疗的累计天数没有差异。在36个月时,在持续或当前海洛因戒断、每日海洛因使用或多药使用水平方面没有组间差异。BPD患者的犯罪、注射相关健康问题、海洛因过量、重度抑郁水平显著更高,整体心理健康状况更差。与12个月随访情况不同,在36个月时,在前12个月内尝试自杀或最近借用用过的注射设备的比例没有组间差异。
自12个月随访以来,临床情况提供了一些乐观的理由。尽管如此,BPD患者在多个领域的风险水平仍然较高。这些风险持续存在这一事实表明,这是一个需要针对与BPD相关风险给予特别临床关注的群体。