Arlazoroff A, Klein C, Meiner Z, Milo R, Theitler J, Carpel C L
Department of Neurology, Assaf Harofeh Medical Center, Tel Aviv, Israel.
Eur Neurol. 1991;31(6):356-9. doi: 10.1159/000116693.
Five female patients with idiopathic torsion dystonia (ITD) responded to treatment with tiapride, a selective D-2 dopamine antagonist. Previous treatments with various drugs, including anticholinergics, were ineffective. It is suggested that the previously reported genetic subgroups of ITD respond to different drug regimens. The autosomal dominant group responded to anticholinergics, while the autosomal recessive group responded best to a selective D-2 dopamine antagonist.
五名患有特发性扭转性肌张力障碍（ITD）的女性患者对选择性D-2多巴胺拮抗剂硫必利的治疗有反应。此前使用包括抗胆碱能药物在内的各种药物进行治疗均无效。有人提出，先前报道的ITD遗传亚组对不同的药物治疗方案有反应。常染色体显性遗传组对抗胆碱能药物有反应，而常染色体隐性遗传组对选择性D-2多巴胺拮抗剂反应最佳。
