Huyton Trevor, Wolberger Cynthia
Department of Biophysics and Biophysical Chemistry, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2185, USA.
Protein Sci. 2007 Jul;16(7):1308-15. doi: 10.1110/ps.072803507. Epub 2007 Jun 13.
The tumor suppressor protein pp32 is highly overexpressed in many cancers of the breast and prostate, and has also been implicated in the neurodegenerative disease spinocerebellar ataxias type 1 (SCA1). Pp32 is a multifunctional protein that is involved in the regulation of transcription, apoptosis, phosphorylation, and cell cycle progression, the latter through its association with the hyperphosphorylated form of the retinoblastoma tumor suppressor. We have determined the structure of an N-terminal pp32 fragment comprising a capped leucine-rich repeat (LRR) domain, which provides insight into the structural and biochemical properties of the pp32 (Anp32) family of proteins.
肿瘤抑制蛋白pp32在许多乳腺癌和前列腺癌中高度过表达，并且也与神经退行性疾病1型脊髓小脑共济失调（SCA1）有关。Pp32是一种多功能蛋白，参与转录、细胞凋亡、磷酸化和细胞周期进程的调控，后者是通过其与视网膜母细胞瘤肿瘤抑制因子的高磷酸化形式相结合来实现的。我们已经确定了一个包含封闭的富含亮氨酸重复序列（LRR）结构域的N端pp32片段的结构，这为深入了解pp32（Anp32）蛋白家族的结构和生化特性提供了线索。
