Bareyre Florence M
Research Unit Therapy Development, Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University Munich, Marchioninistr, 17, 81377 Munich, Germany.
J Neurol Sci. 2008 Feb 15;265(1-2):63-72. doi: 10.1016/j.jns.2007.05.004. Epub 2007 Jun 12.
Spinal cord injury (SCI) often induces loss of motor and/or sensory function below the level of injury. While deficits persist in complete lesions, partial lesions of the spinal cord can be followed by spontaneous functional recovery. In this review we address the mechanisms underlying spontaneous recovery in the adult CNS. We argue that the adult brain and spinal cord are able to spontaneously respond to SCI, and do so by (i) anatomically reorganizing axonal connections and (ii) generating new precursor cells. Knowledge of the endogenous recovery strategies should also provide the basis for the development of new therapeutic strategies for spinal cord injury. In this review we describe the processes of endogenous axonal repair and cell replacement in the injured spinal cord and discuss how transplantation of stem/progenitor cells could enhance these endogenous repair strategies.
脊髓损伤（SCI）常导致损伤平面以下运动和/或感觉功能丧失。在完全性损伤中，功能缺陷持续存在，而脊髓部分损伤后可出现自发功能恢复。在本综述中，我们探讨了成年中枢神经系统自发恢复的潜在机制。我们认为，成年大脑和脊髓能够对脊髓损伤做出自发反应，其方式为：（i）在解剖学上重新组织轴突连接；（ii）产生新的前体细胞。了解内源性恢复策略也应为开发脊髓损伤新治疗策略提供基础。在本综述中，我们描述了损伤脊髓内源性轴突修复和细胞替代的过程，并讨论了干细胞/祖细胞移植如何增强这些内源性修复策略。
