脊髓损伤后功能恢复：利用干细胞和基于活动的疗法促进自发再生。
Restoring function after spinal cord injury: promoting spontaneous regeneration with stem cells and activity-based therapies.
作者信息
Belegu Visar, Oudega Martin, Gary Devin S, McDonald John W
机构信息
The International Center for Spinal Cord Injury, Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, 707 North Broadway, Room 518, Baltimore, MD 21205, USA.
出版信息
Neurosurg Clin N Am. 2007 Jan;18(1):143-68, xi. doi: 10.1016/j.nec.2006.10.012.
Although neural regeneration is an active research field today, no current treatments can aid regeneration after spinal cord injury. This article reviews the feasibility of spinal cord repair and provides an overview of the range of strategies scientists are taking toward regeneration. The major focus of this article is the future role of stem cell transplantation and similar rehabilitative restorative approaches designed to optimize spontaneous regeneration by mobilizing endogenous stem cells and facilitating other cellular mechanisms of regeneration, such as axonal growth and myelination.
尽管神经再生是当今一个活跃的研究领域，但目前尚无治疗方法能够促进脊髓损伤后的再生。本文回顾了脊髓修复的可行性，并概述了科学家们为实现再生所采取的一系列策略。本文的主要重点是干细胞移植以及类似的康复修复方法在未来所发挥的作用，这些方法旨在通过动员内源性干细胞和促进其他再生细胞机制（如轴突生长和髓鞘形成）来优化自然再生。
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