Ding Yan, Chen Zhi-fang, Lin Ren-yong, Wang Xiao-feng, Ding Jian-bing, Ai Xing-zi, Wen Hao
Department of Obstetrics and Gynecology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
Zhonghua Fu Chan Ke Za Zhi. 2004 Feb;39(2):101-4.
To examine the association between glutathione S-transferase (GST)M1, T1 null genotypes and endometriosis of the Uygurs and Hans in Xinjiang.
The polymerase chain reaction method was used to detect the presence or absence of the GSTM1 and GSTT1 genes in genomic DNA from the Uygurs (107 controls and 41 cases) and the Hans (105 controls and 80 cases) in Xinjiang.
The frequencies of the GSTM1-null genotype, GSTT1-null genotype, combined GSTM1-null and GSTT1-null genotype in endometriosis of the Uygurs (51.2%, 36.6%, 24.4%) were not significantly different from those in controls (53.2%, 29.9%, 13.1%). Similarly, no statistically significant difference was observed in the frequency of GSTM1-null genotype in cases of endometriosis of the Hans (56.8%) compared with the controls (51.8%), but the frequencies of GSTT1-null genotype, combined GSTM1-null and GSTT1-null genotype in endometriosis of the Hans (73.7%, 42.5%) were significantly different from those in controls (44.3%, 22.8%). When comparing the Uygurs with the Hans, we found no significant difference in the frequencies of GSTM1-null genotype, GSTT1-null genotype, combined GSTM1-null and GSTT1-null genotype between the two control populations, neither in the frequencies of the GSTM1-null genotype, combined GSTM1-null and GSTT1-null genotype between the two endometriosis populations. However, the frequency of GSTT1-null genotype in cases of the Hans (73.7%) was significantly higher than that in cases of the Uygurs (36.6%).
No evidence was found to suggest an association between GSTM1-null genotype and endometriosis in the Hans and Uygurs. An association was found between GSTT1-null genotype and endometriosis in the Hans, but not in the Uygurs. The two nationalities have different genetic predisposing factors to the development of endometriosis.
探讨谷胱甘肽S-转移酶（GST）M1、T1基因缺失型与新疆维吾尔族和汉族子宫内膜异位症的关系。
采用聚合酶链反应法检测新疆维吾尔族（107例对照和41例病例）和汉族（105例对照和80例病例）基因组DNA中GSTM1和GSTT1基因的有无。
维吾尔族子宫内膜异位症患者中GSTM1基因缺失型、GSTT1基因缺失型、GSTM1和GSTT1基因联合缺失型的频率（51.2%、36.6%、24.4%）与对照组（53.2%、29.9%、13.1%）相比，差异无统计学意义。同样，汉族子宫内膜异位症患者中GSTM1基因缺失型的频率（56.8%）与对照组（51.8%）相比，差异无统计学意义，但汉族子宫内膜异位症患者中GSTT1基因缺失型、GSTM1和GSTT1基因联合缺失型的频率（73.7%、42.5%）与对照组（44.3%、22.8%）相比，差异有统计学意义。比较维吾尔族和汉族时，我们发现两个对照组人群中GSTM1基因缺失型、GSTT1基因缺失型、GSTM1和GSTT1基因联合缺失型的频率，以及两个子宫内膜异位症人群中GSTM1基因缺失型、GSTM1和GSTT1基因联合缺失型的频率均无显著差异。然而，汉族病例中GSTT1基因缺失型的频率（73.7%）显著高于维吾尔族病例（36.6%）。
未发现GSTM1基因缺失型与汉族和维吾尔族子宫内膜异位症之间存在关联。发现GSTT1基因缺失型与汉族子宫内膜异位症有关，但与维吾尔族无关。两个民族在子宫内膜异位症发生发展的遗传易感性因素方面存在差异。
