Giebisch G, Krapf R, Wagner C
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520-8026, USA.
Kidney Int. 2007 Aug;72(4):397-410. doi: 10.1038/sj.ki.5002288. Epub 2007 Jun 13.
The ISN Forefronts in Nephrology Symposium took place 8-11 September 2005 in Kartause Ittingen, Switzerland. It was dedicated to the memory of Robert W. Berliner, who died at age 86 on 5 February 2002. Dr Berliner contributed in a major way to our understanding of potassium transport in the kidney. Starting in the late 1940s, without knowledge of how potassium was transported across specific nephron segments and depending only on renal clearance methods, he and his able associates provided a still-valid blueprint of the basic transport properties of potassium handling by the kidney. They firmly established that potassium was simultaneously reabsorbed and secreted along the nephron; that variations in secretion in the distal nephron segments play a major role in regulating potassium excretion; and that such secretion is modulated by sodium, acid-base factors, hormones, and diuretics. These conclusions were presented in a memorable Harvey Lecture some forty years ago, and they have remained valid ever since. The concepts have also provided the foundation and stimulation for later work on single nephrons, tubule cells, and transport proteins involved in potassium transport.
国际肾脏病前沿研讨会于2005年9月8日至11日在瑞士伊廷根的卡尔特豪斯举行。该研讨会是为纪念罗伯特·W·柏林纳而举办的，他于2002年2月5日去世，享年86岁。柏林纳博士为我们理解肾脏中的钾转运做出了重大贡献。从20世纪40年代末开始，在尚不了解钾如何跨特定肾单位节段转运的情况下，仅依靠肾脏清除率方法，他和他能干的同事们提供了一份至今仍然有效的肾脏处理钾的基本转运特性蓝图。他们明确证实，钾在整个肾单位中同时被重吸收和分泌；远曲小管节段分泌的变化在调节钾排泄中起主要作用；并且这种分泌受钠、酸碱因素、激素和利尿剂的调节。这些结论在大约四十年前的一次令人难忘的哈维讲座中提出，此后一直有效。这些概念也为后来关于单个肾单位、肾小管细胞以及参与钾转运的转运蛋白的研究提供了基础和激励。
