Sherman Morris, Shafran Stephen, Burak Kelly, Doucette Karen, Wong Winnie, Girgrah Nigel, Yoshida Eric, Renner Eberhard, Wong Philip, Deschênes Marc
Department of Medicine, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada.
Can J Gastroenterol. 2007 Jun;21 Suppl C(Suppl C):25C-34C.
Since the last consensus conference on the management of chronic viral hepatitis, a number of studies looking at modifications of the standard course of treatment have been published. These changes have been sufficiently substantive to warrant review to determine whether any changes in the recommended treatment algorithms are needed. A consensus development conference was held in January 2007, and the present document highlights the results of the presentations and discussion about these issues. It reviews the epidemiology of hepatitis C in Canada, treatment of acute hepatitis C and new algorithms in chronic hepatitis C, including retreatment of previous treatment failures. In addition, sections on management of hepatitis C in special populations have been updated. There is also a section on the use of hematopoietic growth factors to help manage patients on therapy. The document should be read in conjunction with the previous document to identify changes. Some recommendations made in the previous document remain and are not discussed here.
自上次关于慢性病毒性肝炎管理的共识会议以来,已经发表了一些关于修改标准治疗疗程的研究。这些变化相当重大,值得进行审查,以确定推荐的治疗算法是否需要任何改变。2007年1月召开了一次共识发展会议,本文件重点介绍了关于这些问题的报告和讨论结果。它回顾了加拿大丙型肝炎的流行病学、急性丙型肝炎的治疗以及慢性丙型肝炎的新算法,包括对先前治疗失败患者的再治疗。此外,关于特殊人群丙型肝炎管理的章节也已更新。还有一节关于使用造血生长因子来帮助管理接受治疗的患者。本文件应与先前的文件一并阅读,以确定其中的变化。先前文件中的一些建议仍然有效,在此不再讨论。