MDM2基因单核苷酸多态性309与胶质母细胞瘤风险及预后无关联。
No association of MDM2 SNP309 with risk of glioblastoma and prognosis.
作者信息
El Hallani Soufiane, Marie Yannick, Idbaih Ahmed, Rodero Mathieu, Boisselier Blandine, Laigle-Donadey Florence, Ducray François, Delattre Jean-Yves, Sanson Marc
机构信息
INSERM, U711, Biologie des Interactions Neurones & Glie, Paris 75013, France.
出版信息
J Neurooncol. 2007 Dec;85(3):241-4. doi: 10.1007/s11060-007-9416-1. Epub 2007 Jun 14.
The MDM2 SNP309 variant has been shown to increase MDM2 expression and to be associated with tumor formation. In glioblastomas, the P53/MDM2 pathway is of crucial importance and MDM2 amplification is related to poor prognosis. However, we show here that MDM2 SNP309 is not associated with glioblastoma risk, and is not a prognostic factor.
MDM2基因SNP309变体已被证明可增加MDM2表达，并与肿瘤形成相关。在胶质母细胞瘤中，P53/MDM2信号通路至关重要，MDM2基因扩增与预后不良有关。然而，我们在此表明，MDM2基因SNP309与胶质母细胞瘤风险无关，也不是一个预后因素。
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