Sibille A, Prat F, Chapelon J Y, Abou el Fadil F, Henry L, Theillère Y, Ponchon T, Cathignol D
Department of Digestive Disease and INSERM U 45, Edouard-Herriot Hospital, Lyon, France.
Oncology. 1993 Sep-Oct;50(5):375-9. doi: 10.1159/000227213.
High-intensity focused ultrasound (HIFU) may produce a well-delineated lesion of coagulation necrosis in deep organs, by means of an extracorporeal transducer. Applications of this method to the liver in animal models have been studied for many years. The effects of HIFU on the normal liver parenchyma and on hepatic tumors are reviewed. In the normal rabbit liver in vivo we showed the relation between intensity levels and exposure times and the need to adapt intensity to the depth of the target. No severe complications were observed when an intensity of 1,000 W/cm2 was used. HIFU is a noninvasive method for the local destruction of liver tumors. In experimental models, safety and efficacy were demonstrated. HIFU may be interesting for the treatment of some human liver tumors.
高强度聚焦超声（HIFU）可通过体外换能器在深部器官产生界限清晰的凝固性坏死病灶。该方法在动物模型肝脏中的应用已研究多年。本文综述了HIFU对正常肝实质和肝肿瘤的影响。在正常兔肝脏活体实验中，我们展示了强度水平与暴露时间之间的关系，以及根据靶深度调整强度的必要性。使用1000W/cm2的强度时未观察到严重并发症。HIFU是一种用于局部破坏肝肿瘤的非侵入性方法。在实验模型中，已证明其安全性和有效性。HIFU可能对某些人类肝肿瘤的治疗具有重要意义。
