Anninos P, Adamopoulos A, Kotini A, Tsagas N, Tamiolakis D, Prassopoulos P
Lab of Medical Physics, Medical School, Democritus University of Thrace, Alex/polis, Greece.
Acta Neurol Belg. 2007 Mar;107(1):5-10.
Magnetoencephalographic (MEG) recordings of Parkinson's diseased (PD) patients were obtained using a whole-head 122-channel magnetometer and analyzed with Fourier statistical analysis. External transcranial magnetic stimulation (TMS) in the order of pico Tesla was applied on the above patients with proper field characteristics (magnetic amplitude : 1-7.5 pT, frequency : the alpha-rhythm of the patient: 8-13 Hz) which were obtained prior to TMS. The MEG recordings after the application of TMS showed a rapid attenuation of the high abnormal activity followed by an increase of the low frequency components toward the patients' alpha-rhythm. The patients responded to the TMS with a feeling of relaxation and partial or complete disappearance of tremor, muscular ache and levodopa induced dyskinesias as well as rapid reversed visuospatial impairment, which were followed by a corresponding improvement and normalization of the MEG.
使用全头122通道磁力计获取帕金森病（PD）患者的脑磁图（MEG）记录，并采用傅里叶统计分析进行分析。对上述患者施加皮特斯拉级别的外部经颅磁刺激（TMS），其具有适当的场特性（磁振幅：1 - 7.5 pT，频率：患者的α节律：8 - 13 Hz），这些特性在TMS之前获得。施加TMS后的MEG记录显示，高异常活动迅速衰减，随后低频成分朝着患者的α节律增加。患者对TMS的反应是感到放松，震颤、肌肉疼痛和左旋多巴诱发的运动障碍部分或完全消失，以及视觉空间障碍迅速逆转，随后MEG相应改善并恢复正常。
