Anninos P, Adamopoulos A, Kotini A, Tsagas N
Lab. of Medical Physics, Medical School, Democritus University of Thrace, Alexandroupoli 68100, Greece.
Lab. of Medical Physics, Medical School, Democritus University of Thrace, Alexandroupoli 68100, Greece.
Mult Scler Relat Disord. 2016 Jul;8:45-53. doi: 10.1016/j.msard.2016.04.008. Epub 2016 Apr 26.
Magnetoencephalographic (MEG) recordings of 10 multiple sclerosis (MS) patients (2 men, 8 women, mean 41.3±9.5 years, mean disease duration 12.7±7.2 years) were obtained using a whole-head 122 - channel MEG system in a magnetically shielded room of low magnetic noise. Our experimental design was double-blind in order to look for possible effect of external pico - Tesla Transcranial Magnetic Stimulation (pT-TMS). The external pT-TMS was applied on the MS patients with proper field characteristics (magnetic field amplitude: 1-7.5pT, frequency: the alpha-rhythm of the patient 8-13Hz) which were obtained prior to the application of pT-TMS. Each MS patient had two separate recording sessions consisting of 3 runs in between where were given real or sham pT-TMS. It was then tried to predict the real and sham stimulation sessions based on the changes in the mean peak frequency difference (MPFD) observed in the brain of the patients in the 2-7Hz frequency band. After unblinding it was found a significant effect of an increase of frequencies in the range of 2-7Hz across the subjects followed by an improvement and normalization of the MEG.
使用全头122通道脑磁图（MEG）系统，在低磁噪声的磁屏蔽室内，对10例多发性硬化症（MS）患者（2名男性，8名女性，平均年龄41.3±9.5岁，平均病程12.7±7.2年）进行了脑磁图记录。我们的实验设计采用双盲法，以寻找外部皮特斯拉经颅磁刺激（pT-TMS）的可能效果。在施加pT-TMS之前，已获取了具有适当场特征（磁场幅度：1-7.5pT，频率：患者的α节律8-13Hz）的外部pT-TMS，并将其应用于MS患者。每位MS患者有两个独立的记录时段，每个时段包括3次运行，其间分别给予真实或假的pT-TMS。然后，试图根据在2-7Hz频段患者大脑中观察到的平均峰值频率差（MPFD）的变化来预测真实和假刺激时段。在揭盲后发现，受试者在2-7Hz范围内频率增加具有显著效果，随后MEG得到改善并恢复正常。
