Chen Lei, Xia Wei-ping, Zhou Zhi-heng
Department of Urology, Longhua Hospital Affiliated to Shanghai University of TCM, Shanghai 200032, China.
Zhonghua Nan Ke Xue. 2007 May;13(5):444-8.
To establish a Wistar rat model of chronic abacterial prostatitis (CAP) by injecting purified prostate protein and Freund's complete adjuvant, and to study the influence on the morphology and proinflammatory expression.
Male rats were injected with the Pertussis-Diphteria-Tetanus vaccine into the abdominal cavity and purified prostate protein and Freund's complete adjuvant intradermally at 0 and 30 days. At 60 days, the rats were sacrificed, and then the prostate specimens were observed, under the light microscope and electron microscope, and the changes of proinflammatory expression was observed too, using PCR technique.
The products of proinflammatory expression, such as eotaxin, iNOS and IL-4 increased markedly. The change of chronic inflammation was shown by light microscope and electron microscope.
Chronic prostatitis is associated with autoimmunity.
通过注射纯化的前列腺蛋白和弗氏完全佐剂建立Wistar大鼠慢性非细菌性前列腺炎（CAP）模型，并研究其对形态学和促炎表达的影响。
雄性大鼠于第0天和第30天腹腔注射百日咳-白喉-破伤风疫苗，并皮内注射纯化的前列腺蛋白和弗氏完全佐剂。第60天处死大鼠，然后在光学显微镜和电子显微镜下观察前列腺标本，并采用PCR技术观察促炎表达的变化。
嗜酸性粒细胞趋化因子、诱导型一氧化氮合酶和白细胞介素-4等促炎表达产物显著增加。光学显微镜和电子显微镜显示有慢性炎症改变。
慢性前列腺炎与自身免疫有关。
