Ramanathan M, Sivakumar S, Anandvijayakumar P R, Saravanababu C, Pandian P Rathinavel
Neuropharmacology Laboratory, Department of Pharmacology, J. S. S. College of Pharmacy, Ootacamund, 643 001, India.
Indian J Exp Biol. 2007 May;45(5):425-31.
The effect of chloroform: methanolic (80:20) extract of C. asiatica (CA; 100 and 200 mg/kg), was evaluated on the course of free radical generation and excitotoxicity in monosodiumglutamate (MSG) treated female Sprague Dawley rats. The extract showed significant improvement in catalase, super oxide desmutase and lipid peroxides levels in hippocampus and striatum regions. Glutathione level was not altered with CA treatment. Similar observation was made with dextromethorphan. The general behavior, locomotor activity and CAl a region of the hippocampus was significantly protected by CA indicating neuroprotective effect of CA in MSG induced excitotoxic condition. Hence it can be concluded that CA protected MSG induced neurodegeneration attributed to its antioxidant and behavioural properties. This activity of CA can be explored in epilepsy, stroke and other degenerative conditions in which the role of glutamate is known to play vital role in the pathogenesis.
甲醇（80:20）提取物（100和200毫克/千克）对经谷氨酸钠（MSG）处理的雌性斯普拉格-道利大鼠自由基生成过程和兴奋性毒性的影响。该提取物使海马体和纹状体区域的过氧化氢酶、超氧化物歧化酶和脂质过氧化物水平有显著改善。积雪草处理后谷胱甘肽水平未改变。右美沙芬也有类似观察结果。积雪草对一般行为、运动活动和海马体CA1区有显著保护作用，表明积雪草在MSG诱导的兴奋性毒性条件下具有神经保护作用。因此可以得出结论，积雪草对MSG诱导的神经退行性变具有保护作用，这归因于其抗氧化和行为特性。积雪草的这种活性可在癫痫、中风和其他退行性疾病中进行探索，在这些疾病中，已知谷氨酸在发病机制中起重要作用。
