Department of Pharmacology, Sree Siddaganga College of Pharmacy, Karnataka, India.
J Environ Pathol Toxicol Oncol. 2012;31(3):213-21. doi: 10.1615/jenvironpatholtoxicoloncol.v31.i3.30.
Monosodium glutamate (MSG) is commonly used as a flavor enhancer in many countries. However, overconsumption of MSG has been reported to produce detrimental effects on several organs. It mainly affects the normal physiology and function of the brain and causes severe oxidative stress. Mimusops elengi Linn. traditionally is used in many countries as a brain tonic and to calm anxiety and panic attacks. The effect of standardized hydroalcoholic extract of M. elengi flowers (ME) was evaluated against MSG-induced oxidative stress and excitotoxicity in Wistar rats. Excitotoxicity was induced by intraperitoneal administration of MSG (2 g/kg) for 7 days, and ME (100 and 200 mg/kg) was administered for 3 days before and for 7 days with administration of MSG. Animals were evaluated for locomotor activity, and brain homogenates were estimated for the levels of antioxidants and nitrite. In animals treated with MSG, pretreatment with ME improved ambulatory behavior, reduced lipid peroxidation and nitrite levels, and restored the enzymatic and nonenzymatic antioxidant (glutathione, total thiols, glutathione-S-transferase and catalase) status to near-normal levels; these were altered in the MSG control animals. Altogether, this investigation demonstrates the neuroprotective effect of ME against excitotoxicity and oxidative stress induced by MSG, and the observed protective effect might be attributed to the potential antioxidant property of ME.
味精（MSG）在许多国家被广泛用作增味剂。然而，过量摄入 MSG 已被报道对多个器官产生有害影响。它主要影响大脑的正常生理和功能，并导致严重的氧化应激。Mimusops elengi Linn. 在许多国家传统上被用作补脑剂，用于缓解焦虑和恐慌发作。评价了 M. elengi 花的标准化水醇提取物（ME）对 Wistar 大鼠 MSG 诱导的氧化应激和兴奋毒性的作用。通过腹腔注射 MSG（2 g/kg）诱导兴奋毒性，连续 7 天，并用 MSG 治疗前 3 天和治疗 7 天期间给予 ME（100 和 200 mg/kg）。评价动物的运动活性，并估计脑匀浆中的抗氧化剂和亚硝酸盐水平。在接受 MSG 治疗的动物中，ME 的预处理改善了步行行为，降低了脂质过氧化和亚硝酸盐水平，并使酶和非酶抗氧化剂（谷胱甘肽、总巯基、谷胱甘肽-S-转移酶和过氧化氢酶）的状态恢复到接近正常水平；在 MSG 对照组动物中这些指标发生了改变。总的来说，这项研究表明 ME 对 MSG 诱导的兴奋毒性和氧化应激具有神经保护作用，观察到的保护作用可能归因于 ME 的潜在抗氧化特性。
