Roider J, Michaud N, Flotte T, Birngruber R
Wellman Laboratories of Photomedicine, Harvard Medical School, Boston, MA 02114.
Fortschr Ophthalmol. 1991;88(5):473-6.
Angiographically visible lesions were produced in the fundus of rabbit eyes with repetitive 5 microseconds pulses and continuous wave exposures with 50-ms to 1-s pulse duration from an modified argon laser (514 nm). The ophthalmoscopic and the fluorescein angiographic findings showed less damage in the neural retina and the choroid after repetitively pulsed irradiation. Light microscopy and transmission electron microscopy showed that the neural retina and the choroid can mostly be spared by using repetitive 5 microseconds pulses, even though the damage to the retinal pigment epithelium is similar to the damage caused by continuous wave irradiation. Possible clinical applications, e.g. for macular edema and central serous retinopathy, are discussed.
使用一台经过改装的氩离子激光（514纳米），通过重复的5微秒脉冲以及持续时间为50毫秒至1秒的连续波曝光，在兔眼眼底产生血管造影可见的病变。检眼镜和荧光素血管造影结果显示，重复脉冲照射后神经视网膜和脉络膜的损伤较小。光学显微镜和透射电子显微镜显示，即使视网膜色素上皮的损伤与连续波照射造成的损伤相似，但使用重复的5微秒脉冲时，神经视网膜和脉络膜大多可以免受损伤。文中还讨论了其可能的临床应用，如用于黄斑水肿和中心性浆液性视网膜病变。
