Das Biswanath, Reddy V Saidi, Krishnaiah M, Sharma A V S, Ravi Kumar K, Rao J Venkateswara, Sridhar V
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Phytochemistry. 2007 Aug;68(15):2029-34. doi: 10.1016/j.phytochem.2007.05.002. Epub 2007 Jun 13.
Chemical examination of the flowers of Parthenium hysterophorus has resulted in the isolation of four acetylated pseudoguaianolides along with several known constituents. The structures of the compounds were derived from detailed studies of their spectral (1D and 2D NMR and FABMS) data and by comparison of the values with those of parthenin, a major known constituent of the plant. The cytotoxic activity of parthenin and the constituents was evaluated using Jurkat (human: T lymphocyte; acute T cell leukemia), HL-60 (human leukemia) and Hela (human cervical carcinoma) cells.
对银胶菊花朵进行化学分析后，分离出了四种乙酰化假愈创木烷型倍半萜内酯以及几种已知成分。通过对其光谱（一维和二维核磁共振以及快原子轰击质谱）数据的详细研究，并将这些数值与该植物的主要已知成分银胶菊素的数值进行比较，确定了这些化合物的结构。使用Jurkat细胞（人：T淋巴细胞；急性T细胞白血病）、HL - 60细胞（人白血病细胞）和Hela细胞（人宫颈癌细胞）评估了银胶菊素及其成分的细胞毒性活性。
