Trifunović Snezana, Vajs Vlatka, Juranić Zorica, Zizak Zeljko, Tesević Vele, Macura Slobodan, Milosavljević Slobodan
Faculty of Chemistry, University of Belgrade, Serbia and Montenegro.
Phytochemistry. 2006 May;67(9):887-93. doi: 10.1016/j.phytochem.2006.02.026. Epub 2006 Apr 17.
Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9-11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound.
对高山蓍草地上部分的研究得到了8种愈创木内酯（1-8）、3种紫穗槐烯（9-11）、4种黄酮醇（12-15）、芝麻素（木脂素）和异秦皮啶（香豆素）。通过光谱方法确定了新化合物（2、4、5、7和10）的结构。测试了化合物2、8、9和12对HeLa、K562和Fem-X人癌细胞系的抗增殖作用。愈创木内酯2（9α-乙酰氧基青蒿内酯）和8（阿普辛）对所有测试细胞系均显示出显著的细胞毒性作用，而紫穗槐烯（9）表现出中等活性。活性最强的是黄酮醇矢车菊素（12），它是一种已知的细胞毒性化合物。
