College of Animal Science & Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, China.
Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, 211100 Nanjing, China.
Molecules. 2020 Jul 22;25(15):3324. doi: 10.3390/molecules25153324.
Traditional synthetic techniques for silver nanoparticles synthesis involve toxic chemicals that are harmful to humans as well as the environment. The green chemistry method for nanoparticle synthesis is rapid, eco-friendly, and less toxic as compared to the traditional methods. In the present research, we synthesized silver nanoparticles employing a green chemistry approach from leaf extract. The optimized parthenium silver nanoparticles (PrSNPs) had a mean particle size of 187.87 ± 4.89 nm with a narrow size distribution of 0.226 ± 0.009 and surface charge -34 ± 3.12 mV, respectively. The physicochemical characterization of optimized SNPs was done by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Moreover, the transmission electron microscopy (TEM) analysis indicates the spherical shape of NPs with an average diameter of 20-25 nm. PrSNPs were investigated for in vitro antibacterial, antifungal, anti-inflammatory, and antioxidant properties, and showed excellent profiles. The cytotoxic activity was analyzed against two cancer cell lines, i.e., B16F10 and HepG2 for 24 h and 48 h. PrSNPs proved to be an excellent anticancer agent. These PrSNPs were also employed for the treatment of wastewater by monitoring the count, and it turned out to be reduced by 58%; hence these NPs could be used for disinfecting water. Hence, we can propose that PrSNPs could be a suitable candidate as an antimicrobial, antioxidant, anti-inflammatory, and antitumor agent for the treatment of several ailments.
传统的银纳米粒子合成技术涉及到对人类和环境都有害的有毒化学物质。与传统方法相比，纳米粒子合成的绿色化学方法快速、环保且毒性较小。在本研究中，我们使用绿色化学方法从叶提取物中合成了银纳米粒子。优化后的银纳米粒子（PrSNPs）的平均粒径为 187.87±4.89nm，粒径分布较窄，为 0.226±0.009，表面电荷为-34±3.12mV。优化后的 SNPs 的物理化学特性通过傅里叶变换红外光谱（FTIR）、热重分析（TGA）和差示扫描量热法（DSC）进行了表征。此外，透射电子显微镜（TEM）分析表明 NPs 呈球形，平均直径为 20-25nm。我们研究了 PrSNPs 的体外抗菌、抗真菌、抗炎和抗氧化特性，结果表明其具有优异的特性。对两种癌细胞系 B16F10 和 HepG2 进行了 24h 和 48h 的细胞毒性活性分析。PrSNPs 被证明是一种优秀的抗癌剂。我们还使用这些 PrSNPs 处理废水，通过监测细菌数量，结果表明细菌数量减少了 58%；因此，这些纳米粒子可用于消毒水。因此，我们可以提出，PrSNPs 可以作为一种合适的候选物，用于治疗多种疾病的抗菌、抗氧化、抗炎和抗肿瘤药物。
