Yu Kuang-hui, See Lai-chu, Huang Yi-ching, Yang Chung-han, Sun Jui-hung
Division of Rheumatology, Chang Gung Memorial Hospital, Chang Gung University, Tao-Yuan, Taiwan, Republic of China.
Semin Arthritis Rheum. 2008 Feb;37(4):243-50. doi: 10.1016/j.semarthrit.2007.04.007. Epub 2007 Jun 14.
Although diet has long been assumed to be associated with hyperuricemia, the association between diet and hyperuricemia remains to be verified.
The Nutrition and Health Survey in Taiwan (NAHSIT) implemented between 1993 and 1996 was a nationwide survey using a stratified multistage sampling design. A food frequency questionnaire (FFQ), 24-hour diet recall, and blood samples were utilized. Hyperuricemia was defined as serum urate >7.7 mg/dL for men and >6.6 mg/dL for women.
In total, 2176 adults, 987 (45%) men and 1189 (55%) women, were recruited. Mean serum urate was 6.81 +/- 1.66 mg/dL (range, 2.5-16.8 mg/dL) and 5.47 +/- 1.55 mg/dL (range, 1.4-11.5 mg/dL) for men and women, respectively. Multiple logistic regression analysis indicated that beer consumption in both the FFQ and the 24-hour diet recall were significantly associated with hyperuricemia in men after adjusting for age, total caloric intake, body mass index, and geographic area. In FFQ, the adjusted odds ratio was 1.49 for men who imbibed 0.1 to 11.6 g ethanol (<1 standard drink) daily and 1.56 for men who imbibed > or =11.7 g ethanol (> or =1 standard drink) daily, when compared with that for men who did not drink beer (P = 0.035). In the 24-hour diet recall, the adjusted odds ratio for men who drank <5 cans of beer daily was 1.13, and for men who drank > or =5 cans daily was 1.28 when compared with that for men who did not drink beer (P = 0.003).
This cross-sectional survey demonstrated that beer intake is independently associated with increased risk of hyperuricemia in men. Restricted beer intake may help prevent hyperuricemia in the population. The finding of elevated mean serum urate levels over recent decades warrants further study.
尽管长期以来人们一直认为饮食与高尿酸血症有关，但饮食与高尿酸血症之间的关联仍有待验证。
1993年至1996年开展的台湾营养与健康调查（NAHSIT）是一项采用分层多阶段抽样设计的全国性调查。使用了食物频率问卷（FFQ）、24小时饮食回顾法和血液样本。高尿酸血症的定义为男性血清尿酸>7.7mg/dL，女性血清尿酸>6.6mg/dL。
共招募了2176名成年人，其中987名（45%）男性和1189名（55%）女性。男性和女性的平均血清尿酸分别为6.81±1.66mg/dL（范围为2.5 - 16.8mg/dL）和5.47±1.55mg/dL（范围为1.4 - 11.5mg/dL）。多因素逻辑回归分析表明，在调整年龄、总热量摄入、体重指数和地理区域后，FFQ和24小时饮食回顾法中啤酒摄入量与男性高尿酸血症均显著相关。在FFQ中，与不喝啤酒的男性相比，每日摄入0.1至11.6g乙醇（<1标准杯）的男性调整后的比值比为1.49，每日摄入≥11.7g乙醇（≥1标准杯）的男性调整后的比值比为1.56（P = 0.035）。在24小时饮食回顾法中，与不喝啤酒的男性相比，每日饮用<5罐啤酒的男性调整后的比值比为1.13，每日饮用≥5罐啤酒的男性调整后的比值比为1.28（P = 0.003）。
这项横断面调查表明，男性啤酒摄入量与高尿酸血症风险增加独立相关。限制啤酒摄入量可能有助于预防人群中的高尿酸血症。近几十年来平均血清尿酸水平升高这一发现值得进一步研究。
