Kobayashi Taisuke, Takahashi Naoki, Hagiwara Yuki, Tamaru Jun-ichi, Kayano Hidekazu, Jin-nai Iturou, Bessho Masami, Niitsu Nozomi
Department of Hematology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan.
Leuk Res. 2008 Jan;32(1):173-5. doi: 10.1016/j.leukres.2007.04.017. Epub 2007 Jun 13.
Primary rectal MALT lymphoma is rare comprising less than 1% of MALT lymphomas. A 26-year-old man was referred to our hospital because of constipation and abdominal fullness. Colonoscopy revealed multiple submucosal tumors in rectum. Histopathological examination showed dense proliferation of small lymphoid cells, but lymphoepithelial lesions were not observed. The cells were CD5(-), CD10(-), CD20(+) and cyclinD1(-). The patient was diagnosed as having MALT lymphoma. The patient was negative for API2-MALT1 gene, and radiotherapy was performed and CR was achieved. With the accumulation of cases, establishment of a treatment strategy for primary rectal MALT lymphoma is expected in the future.
原发性直肠黏膜相关淋巴组织淋巴瘤罕见，占黏膜相关淋巴组织淋巴瘤的比例不到1%。一名26岁男性因便秘和腹部饱胀感被转诊至我院。结肠镜检查发现直肠有多个黏膜下肿瘤。组织病理学检查显示小淋巴细胞密集增殖，但未观察到淋巴上皮病变。细胞CD5(-)、CD10(-)、CD20(+)、细胞周期蛋白D1(-)。该患者被诊断为黏膜相关淋巴组织淋巴瘤。患者API2-MALT1基因检测为阴性，接受了放射治疗并实现了完全缓解。随着病例的积累，未来有望建立原发性直肠黏膜相关淋巴组织淋巴瘤的治疗策略。
