Olff Miranda, de Vries Giel-Jan, Güzelcan Yener, Assies Johanna, Gersons Berthold P R
Center for Psychological Trauma, Department of Psychiatry, Academic Medical Center/de Meren, University of Amsterdam, Tafelbergweg 25, 1105 BC Amsterdam, The Netherlands.
Psychoneuroendocrinology. 2007 Jul;32(6):619-26. doi: 10.1016/j.psyneuen.2007.04.001. Epub 2007 Jun 13.
Post-traumatic stress disorder (PTSD) has been associated with dysregulation of the neuroendocrine system. In this study we examine the effects of psychotherapy in 21 PTSD patients, with and without coexisting depression, on the levels of six stress-related hormones: cortisol, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone-sulfate (DHEA-S), prolactin, thyrotropin (TSH) and free thyroxin (fT4). The results show that after brief eclectic psychotherapy (BEP) significant changes occurred in levels of cortisol and DHEA. Responders showed an increase in cortisol and DHEA levels, while in non-responders both hormone levels decreased. Differences were only found after controlling for depressive symptoms. In conclusion, effective psychotherapy for PTSD may alter dysregulations in the Hypothalamus-pituitary-adrenal (HPA)-axis, but comorbid depressive symptoms should be taken into account.
创伤后应激障碍（PTSD）与神经内分泌系统失调有关。在本研究中，我们检测了21名患有和未患有共病抑郁的PTSD患者接受心理治疗后六种应激相关激素水平的变化：皮质醇、脱氢表雄酮（DHEA）、硫酸脱氢表雄酮（DHEA-S）、催乳素、促甲状腺激素（TSH）和游离甲状腺素（fT4）。结果显示，经过短期折中心理治疗（BEP）后，皮质醇和DHEA水平发生了显著变化。有反应者的皮质醇和DHEA水平升高，而无反应者的这两种激素水平均下降。差异仅在控制抑郁症状后才被发现。总之，有效的PTSD心理治疗可能会改变下丘脑-垂体-肾上腺（HPA）轴的失调，但应考虑共病的抑郁症状。
