Kiortsis D N, Tsouli S, Filippatos T D, Konitsiotis S, Elisaf M S
Laboratory of Physiology, Medical School, University of Ioannina, Panepistimiou Avenue, 45110 Ioannina, Greece.
Nutr Metab Cardiovasc Dis. 2008 Mar;18(3):207-10. doi: 10.1016/j.numecd.2006.10.003. Epub 2007 Jun 13.
Intentional weight loss results in improvement in mood. Very few data exist regarding the effects of sibutramine on the mood of obese and overweight patients in general clinical samples. Moreover, no study has evaluated the effects of orlistat treatment on mood. The purpose of our study was to assess the effects of sibutramine and orlistat on mood in obese and overweight subjects.
Sixty obese and overweight women were divided into three groups. The first group (n=20) received a low-calorie diet and sibutramine 10mg; the second group (n=20) received a low-calorie diet and orlistat 120 mg three times a day, and the third group received only the low-calorie diet.
A psychiatric assessment was performed with the Hamilton Depression Rating Scale (HAMD) before and after 3 months of treatment. In all the groups a statistically significant decrease in HAMD scores was observed. However, the decrease in the sibutramine group was greater compared to that observed in the two other groups (P<0.01). These results suggest that sibutramine treatment may improve mood more than diet alone or orlistat therapy in a general clinical sample of obese patients.
刻意减肥可改善情绪。在一般临床样本中，关于西布曲明对肥胖和超重患者情绪影响的数据极少。此外，尚无研究评估奥利司他治疗对情绪的影响。我们研究的目的是评估西布曲明和奥利司他对肥胖和超重受试者情绪的影响。
60名肥胖和超重女性被分为三组。第一组（n = 20）接受低热量饮食并服用10毫克西布曲明；第二组（n = 20）接受低热量饮食并每天三次服用120毫克奥利司他，第三组仅接受低热量饮食。
在治疗3个月前后，使用汉密尔顿抑郁量表（HAMD）进行精神评估。所有组中，HAMD评分均有统计学显著下降。然而，与其他两组相比，西布曲明组的下降幅度更大（P < 0.01）。这些结果表明，在肥胖患者的一般临床样本中，西布曲明治疗可能比单纯饮食或奥利司他治疗更能改善情绪。
