Ott M M, Müller-Hermelink H K, Schmitt B, Feller A C
Department of Pathology, University of Würzburg, Germany.
Histopathology. 1991 Aug;19(2):163-7. doi: 10.1111/j.1365-2559.1991.tb00007.x.
Twenty-nine cases of non-Hodgkin's lymphoma of low-grade malignancy in a European population were investigated for the presence of bcl-2 and bcl-1 gene rearrangement. The cases were classified according to the Kiel classification. It was shown that bcl-2 gene rearrangements were exclusively confined to centroblastic-centrocytic lymphomas. bcl-1 rearrangements were found in two cases of chronic lymphocytic leukaemia. As the chromosomal translocation t(14;18) is reported to occur in up to 85% of follicular lymphomas, our results provide additional evidence that the differentiation of low-grade B-cell lymphomas according to the Kiel classification defines biologically distinct entities.
对欧洲人群中29例低级别恶性非霍奇金淋巴瘤病例进行了bcl-2和bcl-1基因重排检测。这些病例根据基尔分类法进行分类。结果显示，bcl-2基因重排仅局限于中心母细胞-中心细胞淋巴瘤。在2例慢性淋巴细胞白血病病例中发现了bcl-1重排。由于据报道高达85%的滤泡性淋巴瘤会发生染色体易位t(14;18)，我们的结果提供了额外证据，表明根据基尔分类法对低级别B细胞淋巴瘤进行的区分定义了生物学上不同的实体。
