Grossman Paul, Tiefenthaler-Gilmer Ulrike, Raysz Annette, Kesper Ulrike
Division of Psychosomatic Medicine, Department of Internal Medicine, University of Basel Hospital, Basel, Switzerland.
Psychother Psychosom. 2007;76(4):226-33. doi: 10.1159/000101501.
Mindfulness-based stress reduction (MBSR) proposes a systematic program for reduction of suffering associated with a wide range of medical conditions. Studies suggest improvements in general aspects of well-being, including quality of life (QoL), coping and positive affect, as well as decreased anxiety and depression.
A quasi-experimental study examined effects of an 8-week MBSR intervention among 58 female patients with fibromyalgia (mean, 52 +/- 8 years) who underwent MBSR or an active social support procedure. Participants were assigned to groups by date of entry, and 6 subjects dropped out during the study. Self-report measures were validated German inventories and included the following scales: visual analog pain, pain perception, coping with pain, a symptom checklist and QoL. Pre- and postintervention measurements were made. Additionally, a 3-year follow-up was carried out on a subgroup of 26 participants.
Pre- to postintervention analyses indicated MBSR to provide significantly greater benefits than the control intervention on most dimensions, including visual analog pain, QoL subscales, coping with pain, anxiety, depression and somatic complaints (Cohen d effect size, 0.40-1.10). Three-year follow-up analyses of MBSR participants indicated sustained benefits for these same measures (effect size, 0.50-0.65).
Based upon a quasi-randomized trial and long-term observational follow-up, results indicate mindfulness intervention to be of potential long-term benefit for female fibromyalgia patients.
基于正念减压疗法（MBSR）提出了一个系统性方案，用于减轻与多种医疗状况相关的痛苦。研究表明，该疗法能改善幸福感的多个方面，包括生活质量（QoL）、应对能力和积极情绪，同时还能减轻焦虑和抑郁。
一项准实验研究考察了为期8周的MBSR干预对58名纤维肌痛女性患者（平均年龄52±8岁）的影响，这些患者接受了MBSR或积极的社会支持程序。参与者按入组日期分组，研究期间有6名受试者退出。自我报告测量采用经过验证的德文量表，包括以下量表：视觉模拟疼痛量表、疼痛感知量表、疼痛应对量表、症状清单和生活质量量表。在干预前后进行测量。此外，对26名参与者的亚组进行了为期3年的随访。
干预前至干预后的分析表明，在大多数维度上，MBSR比对照干预提供了显著更大的益处，包括视觉模拟疼痛、生活质量子量表、疼痛应对、焦虑、抑郁和躯体不适（科恩d效应量，0.40 - 1.10）。对MBSR参与者的3年随访分析表明，这些相同测量指标的益处持续存在（效应量，0.50 - 0.65）。
基于一项准随机试验和长期观察随访，结果表明正念干预对女性纤维肌痛患者具有潜在的长期益处。
