Gray J
Dalhousie University, Halifax, Nova Scotia, Canada.
Clin Pharmacol Ther. 2007 Jul;82(1):15-7. doi: 10.1038/sj.clpt.6100261.
Clinical pharmacology is finally crossing the last frontier--the recognition that men and women are different, not just in outward appearance, but also in the way in which they handle drugs. As outlined by Janice Schwartz in this issue, sex differences in drug pharmacokinetics and pharmacodynamics are measurable and, in some instances, may even be significant. This is of particular importance in the elderly, a population frequently requiring multiple drugs and dealing with both the social and health aspects of aging.
临床药理学终于跨越了最后一道前沿——认识到男性和女性存在差异,不仅在外貌上,而且在处理药物的方式上。正如贾尼斯·施瓦茨在本期所概述的,药物药代动力学和药效学中的性别差异是可测量的,在某些情况下,甚至可能很显著。这在老年人中尤为重要,这一人群经常需要多种药物治疗,并且要应对衰老带来的社会和健康问题。