Foulks Gary N
Department of Ophthalmology and Vision Science, University of Louisville, Louisville, KY, USA.
Surv Ophthalmol. 2007 Jul-Aug;52(4):369-74. doi: 10.1016/j.survophthal.2007.04.009.
Dry eye, also known as keratoconjunctivitis sicca, can be due either to insufficient tear production or excessive tear evaporation, both resulting in tear hyperosmolarity that leads to symptoms of discomfort and ocular damage. Additionally, the severity of dry eye symptoms appears to be correlated to lipid layer thickness. It is now generally recognized that increased evaporation due to a compromised lipid layer is one of the most common etiologies for hyperosmolarity of the tear film. Thus, therapies targeted at replenishing or stabilizing the lipid layer are key to the treatment of dry eye, either as monotherapy or in conjunction with therapies designed to enhance aqueous production.
干眼症，也称为角结膜干燥症，可能是由于泪液分泌不足或泪液过度蒸发所致，这两种情况都会导致泪液高渗，进而引发不适症状和眼部损伤。此外，干眼症症状的严重程度似乎与脂质层厚度相关。现在普遍认为，由于脂质层受损导致的蒸发增加是泪膜高渗最常见的病因之一。因此，针对补充或稳定脂质层的治疗方法是干眼症治疗的关键，无论是作为单一疗法还是与旨在增加泪液分泌的疗法联合使用。
