Blum Arnon, Kryuger Konstantin, Mashiach Eizenberg Michal, Tatour Sameh, Vigder Fina, Laster Zvi, Front Eran
Department of Internal Medicine A, Baruch-Padeh Poriya Medical Center, Lower Galilee 15208, Israel.
Eur J Intern Med. 2007 Jul;18(4):295-8. doi: 10.1016/j.ejim.2006.12.003.
Periodontitis is a chronic, infectious, insidious disease of the tooth-supporting structures that causes a general inflammatory response. The aims of this study were to determine whether periodontitis is associated with endothelial dysfunction leading to cardiovascular events and whether proper management of periodontal disease would improve endothelial function and prevent cardiovascular events in the future.
Twenty-two patients (12 women, 10 men; 40+/-5 years old) took part in the study. All had severe periodontitis (without systemic disorders) and were all treated conservatively. Thirteen patients returned for a second visit after 3 months of treatment. Endothelial function and periodontal status were evaluated on entry into the study and 3 months following treatment. Ten age-matched, healthy volunteers without periodontal disease served as the control group.
There was a significant difference between the patient group and the healthy controls: FMD% 4.12+/-3.96 vs. 16.60+/-7.86% (p=0.0000). Periodontitis improved significantly in all 13 patients who completed 3 months of treatment, and their endothelial function improved as well: FMD% 4.12+/-3.96% vs. 11.12+/-7.22% (p=0.007). No difference was found in FID% before and after 3 months of treatment: 20.97+/-10.66% vs.17.94+/-6.23% (p=NS).
Periodontitis may be an insidious cause of endothelial dysfunction and cardiovascular events. Treating periodontitis can improve endothelial function and be an important preventive tool for cardiovascular disease.
牙周炎是一种慢性、感染性、隐匿性的牙齿支持结构疾病，会引发全身性炎症反应。本研究的目的是确定牙周炎是否与导致心血管事件的内皮功能障碍相关，以及牙周疾病的恰当治疗是否会在未来改善内皮功能并预防心血管事件。
22名患者（12名女性，10名男性；年龄40±5岁）参与了本研究。所有患者均患有重度牙周炎（无全身性疾病），且均接受了保守治疗。13名患者在治疗3个月后返回进行第二次就诊。在研究开始时和治疗3个月后评估内皮功能和牙周状况。10名年龄匹配、无牙周疾病的健康志愿者作为对照组。
患者组与健康对照组之间存在显著差异：血流介导的血管舒张百分比（FMD%）为4.12±3.96% 对比 16.60±7.86%（p = 0.0000）。所有完成3个月治疗的13名患者的牙周炎均有显著改善，其内皮功能也得到改善：FMD%为4.12±3.96% 对比 11.12±7.22%（p = 0.007）。治疗3个月前后的内膜-中膜厚度比（FID%）未发现差异：20.97±10.66% 对比 17.94±6.23%（p = 无统计学意义）。
牙周炎可能是内皮功能障碍和心血管事件的隐匿性病因。治疗牙周炎可改善内皮功能，并且是预防心血管疾病的重要手段。
