一例小细胞肺癌自发消退伴副肿瘤性感觉神经病变进展的病例。

A case of spontaneous regression of small cell lung cancer with progression of paraneoplastic sensory neuropathy.

作者信息

Hirano Satoshi, Nakajima Yoshifumi, Morino Eriko, Fujikura Yuji, Mochizuki Makoto, Takeda Yuichiro, Sugiyama Haruhito, Kobayashi Nobuyuki, Tanaka Keiko, Kudo Koichiro

机构信息

Department of Respiratory Medicine, International Medical Center of Japan, 1-21-1, Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.

出版信息

Lung Cancer. 2007 Nov;58(2):291-5. doi: 10.1016/j.lungcan.2007.05.005. Epub 2007 Jun 18.

DOI:10.1016/j.lungcan.2007.05.005

PMID:17574297

Abstract

We report here a rare case of small cell lung cancer (SCLC) accompanied by a partial spontaneous regression with a progression of paraneoplastic sensory neuropathy (PSN). A 55-year-old woman was admitted to our hospital with dry cough and progressive numbness in the distal extremities over 1 month. She was diagnosed as small cell lung cancer associated with paraneoplastic sensory neuropathy. About 1 month later, partial spontaneous regression of tumor with a progression of paraneoplastic sensory neuropathy was observed. A complete response was achieved through chemotherapy and concurrent radiotherapy. As the tumor size decreased, her neurological symptoms improved. A short interval between onset of PSN and the start of therapy may be essential for successful treatment for not only SCLC but also PSN.

摘要

我们在此报告一例罕见的小细胞肺癌（SCLC）病例，该病例伴有肿瘤部分自发消退以及副肿瘤性感觉神经病变（PSN）进展。一名55岁女性因干咳及1个月来四肢远端进行性麻木入住我院。她被诊断为与副肿瘤性感觉神经病变相关的小细胞肺癌。约1个月后，观察到肿瘤部分自发消退且副肿瘤性感觉神经病变进展。通过化疗和同步放疗实现了完全缓解。随着肿瘤大小减小，她的神经症状有所改善。PSN发病与治疗开始之间的短时间间隔对于SCLC和PSN的成功治疗可能至关重要。