与兰伯特-伊顿肌无力综合征相关的小细胞肺癌自发性消退：病例报告
Spontaneous regression of small cell lung cancer associated with Lambert-Eaton Myasthenic Syndrome: Case report.
作者信息
Otani Michimi, Nishimori Miki, Iwasa Hitomi, Iwamura Mamiko, Izumi Takayasu, Nakaji Kosuke, Nitta Noriko, Miyatake Kana, Yoshimatsu Rika, Yamanishi Tomoaki, Matsumoto Tomohiro, Osaki Yasushi, Wada Noriko, Toi Makoto, Yamamoto Marino, Nakatani Yu, Kubota Tetsuya, Yamagami Takuji
机构信息
Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan.
Department of Neurology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, Japan.
出版信息
Radiol Case Rep. 2023 Sep 2;18(11):4036-4041. doi: 10.1016/j.radcr.2023.08.059. eCollection 2023 Nov.
Spontaneous regression (SR) of cancer is very rare, especially of small cell lung cancer (SCLC). Recently, an association of paraneoplastic neurological syndrome (PNS) has been reported as a cause of SR of cancer, and onconeural antibodies are a possible factor in the SR of cancer associated with PNS. We herein report the first case of SR of SCLC combined with anti-P/Q-type of voltage-gated calcium channel (VGCC) antibody-positive Lambert-Eaton myasthenic syndrome (LEMS), a subtype of PNS. This case report suggests that SCLC may be spontaneously reduced by an autoimmune response induced by VGCC antibodies associated with LEMS. Our finding may help elucidate the mechanisms that inhibit tumor growth and cause the regression of tumors.
癌症的自发消退（SR）非常罕见，尤其是小细胞肺癌（SCLC）。最近，有报道称副肿瘤性神经综合征（PNS）与癌症的自发消退有关，而肿瘤神经抗体是与PNS相关的癌症自发消退的一个可能因素。我们在此报告首例小细胞肺癌自发消退合并抗P/Q型电压门控钙通道（VGCC）抗体阳性的兰伯特-伊顿肌无力综合征（LEMS），这是PNS的一种亚型。本病例报告表明，与LEMS相关的VGCC抗体诱导的自身免疫反应可能使小细胞肺癌自发缩小。我们的发现可能有助于阐明抑制肿瘤生长并导致肿瘤消退的机制。
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