Cuillerier E, Coffin B, Potet F, Dapoigny M, Flourie B, Coffin J C, Benyahia B, Bitoun A, Messing B, Rambaud J C
Service de Gastroentérologie, Hôpital Saint-Lazare, Paris.
Gastroenterol Clin Biol. 1998 Mar;22(3):346-8.
A 67-year-old woman was admitted for intestinal pseudoobstruction associated with peripheral sensitive neuropathy. Jejunal biopsies performed during laparotomy, showed axonal degeneration and lympho-plasmocytic infiltration in myenteric plexus. High titer of seric anti-Hu antibodies suggested a paraneoplastic syndrome. Thoracic CT scan showed mediastinal lymph nodes. Their histological examination confirmed the diagnosis of metastatic small-cell lung carcinoma. Her condition gradually deteriorated despite supportive parenteral nutrition, chemotherapy, steroids and intravenous immunoglobulins. She died 12 months after the onset of symptoms.
一名67岁女性因肠道假性梗阻合并周围感觉神经病变入院。剖腹手术期间进行的空肠活检显示肌间神经丛存在轴索性变性和淋巴细胞 - 浆细胞浸润。高滴度的血清抗Hu抗体提示副肿瘤综合征。胸部CT扫描显示纵隔淋巴结。其组织学检查确诊为转移性小细胞肺癌。尽管给予了支持性肠外营养、化疗、类固醇和静脉注射免疫球蛋白,她的病情仍逐渐恶化。症状出现12个月后死亡。