Dodson Jennifer L, Diener-West Marie, Gerson Arlene C, Kaskel Frederick J, Furth Susan L
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
J Urol. 2007 Aug;178(2):660-5; discussion 665. doi: 10.1016/j.juro.2007.04.008. Epub 2007 Jun 15.
We examined health related quality of life in adolescents with congenital urological disease causing kidney disease using a generic health related quality of life instrument. We then compared the results to those in adolescents with medical kidney disease and to population based norms.
The Child Health and Illness Profile-Adolescent Edition was administered to 113 patients 10 to 18 years old with chronic kidney disease. Mean domain and subdomain scores for adolescents with urological disease were compared to those of adolescents with medical kidney disease and to population based norms.
The cohort included adolescents with an underlying diagnosis of congenital urological anomaly (37 patients) or other causes of kidney disease (76). Compared to adolescents with kidney disease caused by other factors, those with congenital urological disease scored statistically significantly better in the Child Health and Illness Profile-Adolescent Edition subdomain of Limitations of Activity (mean 22.3 [SD 2.5] vs 20.4 [SD 5.0], p = 0.04). Compared to population norms, adolescents with congenital disorders scored lower in the Disorders domain (mean 16.5, 95% CI 14.2 to 18.9) but better in the Risks domain (mean 25.9, 95% CI 25.1 to 26.6) and in the Home Safety and Health subdomain (mean 25.2, 95% CI 23.7 to 26.6).
As assessed by the Child Health and Illness Profile-Adolescent Edition generic health status questionnaire, adolescents with kidney disease due to underlying congenital urological disease had fewer limitations of activity compared to those with underlying medical kidney disease. Except for low scores in the Disorders domain, children with underlying urological disease did not have significant impairments in any other domain compared to population based norms.
我们使用一种通用的健康相关生活质量工具，对患有先天性泌尿系统疾病并导致肾脏疾病的青少年的健康相关生活质量进行了研究。然后我们将结果与患有医源性肾脏疾病的青少年以及基于人群的标准进行了比较。
对113名10至18岁的慢性肾脏病患者进行了《儿童健康与疾病概况-青少年版》调查。将泌尿系统疾病青少年的平均领域和子领域得分与医源性肾脏疾病青少年以及基于人群的标准进行比较。
该队列包括潜在诊断为先天性泌尿系统异常的青少年（37例）或其他肾脏疾病原因的青少年（76例）。与由其他因素导致肾脏疾病的青少年相比，患有先天性泌尿系统疾病的青少年在《儿童健康与疾病概况-青少年版》的活动受限子领域得分在统计学上显著更高（平均值22.3[标准差2.5]对20.4[标准差5.0]，p = 0.04）。与人群标准相比，患有先天性疾病的青少年在疾病领域得分较低（平均值16.5，95%置信区间14.2至18.9），但在风险领域得分较高（平均值25.9，95%置信区间25.1至26.6）以及在家居安全与健康子领域得分较高（平均值25.2，95%置信区间23.7至26.6）。
通过《儿童健康与疾病概况-青少年版》通用健康状况问卷评估，与患有医源性肾脏疾病的青少年相比，因潜在先天性泌尿系统疾病导致肾脏疾病的青少年活动受限较少。与基于人群的标准相比，除了在疾病领域得分较低外，患有潜在泌尿系统疾病的儿童在任何其他领域均无显著损害。
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