小细胞肺癌产生唾液型淀粉酶：一例报告并文献复习

Small-cell lung carcinoma produces salivary-type amylase: a case report with review.

作者信息

Yamazaki Seiichi, Ebisawa Shoichiro, Yasuo Masanori, Urushihata Kazuhisa, Koizumi Tomonobu, Fujimoto Keisaku, Kubo Keishi

机构信息

First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto.

出版信息

Intern Med. 2007;46(12):883-7. doi: 10.2169/internalmedicine.46.6205. Epub 2007 Jun 15.

DOI:10.2169/internalmedicine.46.6205

PMID:17575383

Abstract

A 53-year-old woman diagnosed with small-cell lung carcinoma (SCLC) was referred to our hospital because of general malaise and inappetence. Serum amylase levels were drastically elevated at 13,920 IU/l, with the salivary type dominating. She suffered multiple liver metastases and presented with disseminated intravascular coagulation (DIC). She succumbed to progressive malaise one month after admission. The amylase level was increased to 18,630 IU/l just before her death. Necropsy of the right supraclavicular lymph node confirmed SCLC with partial necrosis. Immunohistological analysis revealed that the SCLC produced salivary-type amylase. A rare case of salivary-type amylase-producing SCLC with a futile outcome was reported with review of the previous literature.

摘要

一名53岁被诊断为小细胞肺癌（SCLC）的女性因全身不适和食欲不振转诊至我院。血清淀粉酶水平急剧升高至13920 IU/l，以唾液型为主。她出现多处肝转移并伴有弥散性血管内凝血（DIC）。入院一个月后，她因病情逐渐加重而死亡。就在她去世前，淀粉酶水平升至18630 IU/l。右锁骨上淋巴结尸检证实为小细胞肺癌伴部分坏死。免疫组织学分析显示，该小细胞肺癌产生唾液型淀粉酶。结合既往文献回顾，报道了一例罕见的产生唾液型淀粉酶的小细胞肺癌，预后不良。