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常规途径:战后法国对同位素的管控与生物医学研究的开展

Normal pathways: controlling isotopes and building biomedical research in postwar France.

作者信息

Gaudillière Jean-Paul

机构信息

Centre de Recherche Médecine Sciences Santé et Socété, INSERM, Site CNRS, 7 rue Guy Môquet, Villejuif F-94801, France.

出版信息

J Hist Biol. 2006 Winter;39(4):737-64. doi: 10.1007/s10739-006-9111-7.

Abstract

During the late 1940s and 1950s, radioisotopes became important resources for biological and medical research. This article explores the strategies used by French researchers to get access to this material, either from the local Atomic Energy Commission (CEA) or from suppliers in the United States or United Kingdom. It focuses on two aspects of this process: the transatlantic circulation of both isotopes and associated instrumentation; the regulation of use and access by the administrative bodies governing research in France. Analyzing the investigations conducted within laboratories associated either with the atomic energy agency or with the local National Institute of Health (INH), the paper discusses the part played by the new tools in the postwar transformation of biomedical research. It contrasts the INH successful development of biological studies and metabolic tracing with the mixed results of CEA in advancing cancer radiotherapy, thus highlighting locally defined "normal paths" to radiobiology.

摘要

在20世纪40年代末和50年代,放射性同位素成为生物学和医学研究的重要资源。本文探讨了法国研究人员获取这种材料的策略,这些材料要么来自当地的原子能委员会(CEA),要么来自美国或英国的供应商。它关注这一过程的两个方面:同位素和相关仪器的跨大西洋流通;法国管理研究的行政机构对使用和获取的监管。通过分析与原子能机构或当地国家卫生研究所(INH)相关的实验室所进行的调查,本文讨论了这些新工具在战后生物医学研究转型中所起的作用。它将INH在生物学研究和代谢追踪方面的成功发展与CEA在推进癌症放射治疗方面的喜忧参半的结果进行了对比,从而突出了放射生物学在当地定义的“正常路径”。

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