Santos M J, Capela S, Figueira R, Nero P, Matos A Alves, Silva C, Miranda L, Barcelos A, Marques A, Teixeira A, Branco J, da Silva J Canas, de Queiroz M Viana
Servicio de Reumatologia do Hospital Garcia de Orta, Almada.
Acta Reumatol Port. 2007 Apr-Jun;32(2):153-61.
To characterize systemic lupus erythematosus (SLE) in Portuguese patients and to identify differences in diseases expression related to sex and ethnicity.
Retrospective cohort analysis of patients with SLE followed at five Rheumatology Departments between 1976 and 2006. Demographic data, diseases manifestations, medications used, co morbidity and damage scores were recorded.
Five hundred forty four patients were studied, 93% female, 89% Caucasians, with an average age at disease diagnosis of 35 years. The most frequent clinical features were musculoskeletal (91%), cutaneous and mucous membrane (90%) and the hematological involvement (58%). Renal diseases and serositis occurred more often in males while myositis was more common in black patients. Immunological features included the presence of anti-nuclear antibodies in 99% of the patients, anti-DNA (76%) anti-SSA (33%), anti-SSB (20%), anti-RNP (26%), anti-Sm (22%), anticardiolipine (31%) and lupus anticoagulant (21%). Anti-SSA, anti-RNP, and anti-Sm antibodies were significantly more prevalent among black patients. The presence and severity of damage measured by SLICC/ACR was similar between sexes and ethnicities. In multivariate analyses diseases duration and the presence of hypertension showed a positive association, while educational and antimalarials were negatively associated with the presence of damage.
In this cohort of Portuguese patients SLE present clinical features similar to those observed in other predominantly Caucasian populations, albeit a higher prevalence of anti-RNP and anti-Sm antibodies was observed. Some particular features were associated with male sex and African ethnicity. Some socio-demographic and clinical variables were associated with damage accrual.
描述葡萄牙患者的系统性红斑狼疮（SLE），并确定与性别和种族相关的疾病表现差异。
对1976年至2006年间在五个风湿病科就诊的SLE患者进行回顾性队列分析。记录人口统计学数据、疾病表现、使用的药物、合并症和损伤评分。
共研究了544例患者，93%为女性，89%为白种人，疾病诊断时的平均年龄为35岁。最常见的临床特征为肌肉骨骼症状（91%）、皮肤和黏膜症状（90%）以及血液系统受累（58%）。肾脏疾病和浆膜炎在男性中更常见，而肌炎在黑人患者中更常见。免疫学特征包括99%的患者存在抗核抗体、抗双链DNA（76%）、抗SSA（33%）、抗SSB（20%）、抗RNP（26%）、抗Sm（22%）、抗心磷脂（31%）和狼疮抗凝物（21%）。抗SSA、抗RNP和抗Sm抗体在黑人患者中显著更常见。通过SLICC/ACR测量的损伤的存在和严重程度在性别和种族之间相似。在多变量分析中，疾病持续时间和高血压的存在呈正相关，而教育程度和抗疟药与损伤的存在呈负相关。
在这组葡萄牙患者中，SLE的临床特征与其他主要为白种人的人群中观察到的相似，尽管抗RNP和抗Sm抗体的患病率较高。一些特定特征与男性性别和非洲种族相关。一些社会人口统计学和临床变量与损伤累积相关。
