Jallouli Moez, Frigui Makram, Hmida Mohamed Ben, Marzouk Sameh, Kaddour Neila, Bahloul Zouheir
Department of Internal Medicine, Hedi Chaker University Hospital, Sfax, Tunisia.
Saudi J Kidney Dis Transpl. 2008 Nov;19(6):1001-8.
The objective of this study was to determine the main clinical and laboratory features as well as the morbidity and mortality of systemic lupus erythematosus (SLE) in a population of patients predominantly from the south of Tunisia. A retrospective review of a well documented population of 146 patients with SLE was undertaken. All patients fulfilled four or more criteria defined by the American College of Rheumatology. The mean age at presentation was 29.2 years (range 6-55) and the mean duration of follow-up was 62 months (range 0.25-374). Musculoskeletal (84.2%) and mucocutaneous (75.3%) were the most frequent clinical manifestations. Antinuclear antibodies were detected in 97.3%, anti-DNA antibodies in 69.2% and anti-Sm in 39.2% of the patients. Anti-cardiolipin antibodies and lupus anticoagulant were ob-served respectively in 71.6% and 37.8% of the patients. The five-year survival rate in our series was 92%. Renal involvement and thrombocytopenia were associated with poor prognosis (p< 0.05). The clinical and immunological characteristics of our SLE patients are largely comparable to most major studies. Main differences included prominent major organ damage and high pre-valence of anti-Sm and anti-cardiolipin antibodies.
本研究的目的是确定主要来自突尼斯南部人群中系统性红斑狼疮（SLE）的主要临床和实验室特征以及发病率和死亡率。对146例有充分记录的SLE患者进行了回顾性研究。所有患者均符合美国风湿病学会定义的四项或更多标准。就诊时的平均年龄为29.2岁（范围6 - 55岁），平均随访时间为62个月（范围0.25 - 374个月）。肌肉骨骼（84.2%）和黏膜皮肤（75.3%）是最常见的临床表现。97.3%的患者检测到抗核抗体，69.2%检测到抗DNA抗体，39.2%检测到抗Sm抗体。分别在71.6%和37.8%的患者中观察到抗心磷脂抗体和狼疮抗凝物。我们系列中的五年生存率为92%。肾脏受累和血小板减少与预后不良相关（p<0.05）。我们SLE患者的临床和免疫学特征在很大程度上与大多数主要研究相当。主要差异包括明显的主要器官损害以及抗Sm和抗心磷脂抗体的高患病率。
